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夜雨聆风 > > 办公文件 > 罗氏子公司Chugai|面向胞内难靶、突破五规则的口服药物创制新方法验证

罗氏子公司Chugai|面向胞内难靶、突破五规则的口服药物创制新方法验证

当前时间： 2026-05-24 13:41:04 分类：办公文件 评论(0)
罗氏子公司Chugai|面向胞内难靶、突破五规则的口服药物创制新方法验证

本文建立了超越Lipinski五规则（bRo5）的口服环肽成药标准，首次用11残基、高N-烷基化、高亲脂性环肽实现口服、胞内穿透、抑制KRAS，并推进至临床化合物LUNA18。一、核心成药结论1最佳肽环长度：11个残基最优化，通透性与代谢稳定性平衡最好；8个残基易代谢过快，10/...

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  145. /yingpanguazai/ssd/ssd1/www/wwww.yeyulingfeng.com/vendor/topthink/think-trace/src/Html.php ( 4.42 KB )
  1. CONNECT:[ UseTime:0.001053s ] mysql:host=127.0.0.1;port=3306;dbname=wenku;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.001303s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000729s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.001353s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.001210s ]
  6. SELECT * FROM `set` [ RunTime:0.000856s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.001236s ]
  8. SELECT * FROM `article` WHERE `id` = 660335 LIMIT 1 [ RunTime:0.013886s ]
  9. UPDATE `article` SET `lasttime` = 1779604226 WHERE `id` = 660335 [ RunTime:0.037050s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 64 LIMIT 1 [ RunTime:0.001860s ]
  11. SELECT * FROM `article` WHERE `id` < 660335 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.001085s ]
  12. SELECT * FROM `article` WHERE `id` > 660335 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.013307s ]
  13. SELECT * FROM `article` WHERE `id` < 660335 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.013651s ]
  14. SELECT * FROM `article` WHERE `id` < 660335 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.001911s ]
  15. SELECT * FROM `article` WHERE `id` < 660335 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.007940s ]
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