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下面这款帽子是专为生物学子设计,logo为纯手工刺绣的凝胶电泳图,喜欢的朋友可以点击下面卡片,拍一顶,绝对个性十足!!谢谢支持~
AI现在有融入到我们生活中的方法面面吗?有改变我们的生活和工作方式吗?有给我们带来便利吗?我觉得答案是肯定的。
我们老板经常警示我们,“AI马上就要取代我们,更准确的说是首先取代我们”。吓得我赶紧打开招聘软件……
话说回来,AI的大潮已经来了,躲是躲不掉了,需要积极地拥抱,多看看能给我们带来哪些好处。还是跟上潮流,多了解了解,学着用吧,所谓“与时俱进”。
最近,关注到“AI辅助写作”这个话题,于是想找来相关文章读一读。首先,要分享一篇2026年发表的论文,题为“PaperOrchestra: A Multi-Agent Framework for Automated AI Research Paper Writing”(PaperOrchestra:一个用于自动化撰写人工智能研究论文的多智能体框架)。

PaperOrchestra 用户通过提供:
研究思路概述 (I):简要概述所提出的研究方法、核心贡献及理论基础。
实验日志 (E):实验结果汇编,涵盖原始数据点、消融实验及性能指标。
LaTeX 模板 (T):目标人工智能会议提供的模板文件。
会议指南 (G):目标人工智能会议规定的要求。
图示 (F):一组可选的现有视觉素材(例如图表、曲线图),最终输出可供提交的PDF文本。文中给出了工作流示意图,如下:


整体流程:服务器安装Node → 安装Claude CLI → 部署PaperOrchestra技能包 + 生成肠道微生物测试素材 → 配置密钥并执行论文生成管道。(以下内容由AI生成)
代码块1:Linux服务器预装Node.js(Claude Code依赖,Ubuntu/Debian通用)
# 1. 添加Node LTS官方源curl -fsSL https://deb.nodesource.com/setup_lts.x | sudo -E bash -# 2. 安装node+npmsudo apt-get install -y nodejs# 3. 验证版本(要求≥18)node --versionnpm --version# 4. 国内npm镜像加速,解决安装超时npm config set registry https://registry.tuna.tsinghua.edu.cn# 5. 全局安装Claude Code CLIsudo npm install -g @anthropic-ai/claude-code# 6. 验证claude命令是否可用claude --version# 7. 创建Claude全局技能目录(服务器家目录)mkdir -p ~/.claude/skills代码块2:国内加速拉取PaperOrchestra仓库 + 生成论文标准肠道微生物素材(相对路径)
# 修复git 443超时报错git config --global http.postBuffer 524288000git config --global http.timeout 180# 国内镜像克隆仓库git clone https://gitclone.com/github.com/Ar9av/PaperOrchestra.gitcd ./PaperOrchestra# 软链接技能到claude全局目录(服务器永久生效)ln -sf $(pwd)/skills ~/.claude/skills/paper-orchestra# 创建论文标准工作目录(相对路径,全程不写绝对/home)mkdir -p workspace/inputs workspace/output workspace/figures# 生成Sparse Idea(论文标准输入I)cat > workspace/inputs/idea_sparse.md << EOF# Research Topic: Resistant starch intervention modulates gut microbiota and metabolic signaling in type 2 diabetes patients## Research BackgroundType 2 diabetes (T2D) is accompanied by gut dysbiosis, elevated Firmicutes/Bacteroidetes ratio and depleted short-chain fatty acid producers. Current probiotic supplements cannot replicate long-term dietary intervention effects supported by multi-omics human cohort evidence.## Research Gaps1. The synergistic regulatory effects of resistant starch on gut flora, bile acid metabolism and intestinal barrier remain unclear;2. No 6-month randomized controlled human cohort integrating 16S rRNA, metagenomics and untargeted metabolomics;3. No predictive model for T2 dietary response built on core gut microbes.## Core Innovations1. 60-subject 6-month RCT with high-resistant-starch dietary intervention;2. Multi-omics integration to characterize functional strains Faecalibacterium, Akkermansia;3. Random forest model to predict individual intervention response based on gut signatures.## Research SignificanceProvide microbial biomarkers and theoretical basis for personalized fiber intervention in T2D.EOF# 生成Experimental Log(论文标准输入E)cat > workspace/inputs/experimental_summary.md << EOF# Experimental Log## Cohort Design60 newly diagnosed T2 patients randomized to intervention (25g daily resistant starch) / control (regular corn starch), 6-month follow-up. Fecal and fasting serum collected every 2 months.## Sequencing Platform16S V3-V4: Illumina MiSeq; Whole metagenome: NovaSeq; Serum untargeted LC-MS metabolomics.## Bioinformatics PipelineQIIME2 for 16S taxonomic annotation; MetaCyc & KEGG pathway analysis; MaAsLin2 multi-variable correlation; random forest predictive modeling.## Core Quantitative Results1. HbA1c reduced by 0.82%, fasting glucose -1.35 mmol/L in intervention group (P<0.01);2. Shannon & Chao1 diversity increased; F/B ratio dropped from 1.87 to 1.12 (P<0.001);3. Faecalibacterium prausnitzii, Akkermansia muciniphila significantly enriched; Desulfovibrio reduced by 42%;4. Fecal butyrate +47%, serum secondary bile acid GUDCA upregulated, inhibits TLR4/NF-κB intestinal inflammation;5. Prediction model AUC=0.86, superior to clinical-only baseline (AUC=0.71).## Figure ListFig1 Alpha diversity boxplot; Fig2 Phylum-level stacked bar; Fig3 LEfSe differential species; Fig4 Flora-metabolite heatmap; Fig5 ROC curve of predictive modelEOF# 种子参考文献 seed_refs.bibcat > workspace/inputs/seed_refs.bib << EOF@article{qin2012human, title={A human gut microbial gene catalogue established by metagenomic sequencing}, journal={Nature}, volume={464}, pages={59--65}, year={2012}}@article{cani2011gut, title={Gut microbiota and insulin resistance}, journal={Current Opinion in Lipidology}, volume={22}, pages={173--178}, year={2011}}@article{zhao2018dietary, title={Dietary resistant starch shapes gut microbiota and improves glucose homeostasis in type 2 diabetes}, journal={The American Journal of Clinical Nutrition}, volume={108}, pages={354--363}, year={2018}@article{falony2016population, title={Population-level analysis of gut microbiome variation}, journal={Science}, volume={352}, pages={560--564}, year={2016}EOFecho"素材生成完成,相对路径:./workspace/inputs"ls ./workspace/inputs代码块3:服务器永久配置Claude API密钥
# 写入环境变量到bash配置,永久生效(替换为你的sk-ant密钥)echo'export ANTHROPIC_API_KEY="sk-ant-你的完整Claude API密钥"' >> ~/.bashrc# 立即加载环境变量,无需重连服务器source ~/.bashrc# 验证密钥是否加载成功echo$ANTHROPIC_API_KEY# 进入claude交互式终端(服务器本地运行AI对话)claude进入claude交互界面后粘贴完整管道指令(严格对标论文Figure1五智能体7阶段)
Load paper-orchestra skill# 相对工作目录Set workspace path = "./workspace"# 启用论文全部5底层智能体:Outline / Plotting / Literature / Section Writing / Content RefinementEnable all 5 core agents per paper Figure1 architecture# 按7个业务阶段完整执行(底层仍为论文5步并行架构)Stage 1:加载./workspace/inputs素材,运行Outline Agent生成完整JSON大纲(绘图计划、文献检索策略、分章节写作要点)【对应论文Step1】Stage 2:并行执行Plotting Agent,生成所有图表与图注【对应论文Step2】Stage 3:并行执行Literature Agent,联网检索、校验文献,生成规范bib库【对应论文Step3】Stage 4:整合图表与引文,运行Section Writing Agent生成完整论文初稿【对应论文Step4】Stage 5:全文统一术语、消除矛盾冗余,完成初稿初润Stage 6:启动Content Refinement Agent,执行3轮模拟同行评审迭代优化【对应论文Step5】Stage 7:格式化输出,拆分生成3份标准源文件,自动写入./workspace/output# 输出规范:自动落地3份可编辑原始文件1. Paper.md 论文纯文本稿件2. Manuscript.tex 可独立编译LaTeX源码3. References.bib 参考文献库# 领域:肠道微生物+2型糖尿病,生物医学SCI格式,禁止截断、禁止编造数据/文献# 最终说明:流水线仅输出源文件,PDF需自行编译代码块4:AI生成完成后,编译为PDF(MobaXterm终端执行)
cd ./workspace/output# 编译生成FinalSubmission-ready PDFpdflatex Manuscript.texbibtex Referencespdflatex Manuscript.texpdflatex Manuscript.tex# 最终成品:Manuscript.pdf 即论文提交终稿ls Manuscript.pdf前置依赖:必须持有官方Anthropic付费API Key,免费网页账号无法在服务器Claude CLI调用模型。上面的内容需要有梯子,否则不能用claude code,遗憾我用不了,没有办法测试流程是否可以跑通,因此,仅供参考。据说可以用DeepSeek大模型代替claude code,后续我再发文更新相关情况。
总之,这种通过智能体辅助学术写作还是一种非常新颖的方式,值得关注和尝试。
Animal Immunization, in Vitro Display Technologies, and Machine Learning for Antibody Discovery
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